D-Type Cyclins in Development and Disease

D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining exit and progression. Precise control of is vital during embryonic development, with defects the pathways regulating intracellular resulting abnormal initiation stem differentiation variety different organ systems. Furthermore, stabilisation observed wide range disorders characterized by cellular over-proliferation, including cancers overgrowth disorders. In this review, we will summarize compare roles played each cyclin development provide examples how their dysregulation can be an underlying cause disease.